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J Trop Pediatr. 2013 Jun;59(3):209-13. doi: 10.1093/tropej/fmt003. Epub 2013 Feb 13.

Effect of topical application of chlorhexidine for umbilical cord care in comparison with conventional dry cord care on the risk of neonatal sepsis: a randomized controlled trial.

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Department of Pediatrics, Pandit B.D.Sharma Postgraduate Institute of Medical Sciences, Rohtak, Haryana 124001, India.



To compare topical application of chlorhexidine for umbilical cord care with conventional dry care for prevention of neonatal sepsis in neonatal intensive care unit (NICU).


The study was conducted in the NICU of a teaching hospital in north India between 2010 and 2011. Newborns (≥ 32 weeks of gestation and weighing ≥ 1500 g) were randomized into chlorhexidine application and dry care groups. Data regarding time of cord separation, umbilical sepsis and neonatal sepsis were recorded.


One hundred forty (dry care group 70, chlorhexidine group 70) were enrolled and finally analysed. A significant difference was observed among groups in terms of time to cord separation and incidence of blood culture-proven sepsis though there was no statistical difference noted among the groups with regards to umbilical infection, probable sepsis and meningitis.


Use of chlorhexidine for umbilical cord care prevents sepsis in the NICU.

[Indexed for MEDLINE]

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