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Int J Tuberc Lung Dis. 2013 Mar;17(3):333-5. doi: 10.5588/ijtld.12.0427.

The pharmacokinetics of nevirapine when given with isoniazid in South African HIV-infected individuals.

Author information

1
Division of Clinical Pharmacology, Department of Medicine, Groote Schuur Hospital University of Cape Town, Cape Town, South Africa.

Abstract

Isoniazid preventive therapy (IPT) is recommended in patients on antiretroviral treatment. Isoniazid (INH) inhibits CYP3A4, which metabolises nevirapine (NVP). Administration of INH may cause higher NVP concentrations and toxicity. We studied the effect of INH on NVP concentrations in 21 patients randomised to either placebo (n = 13) or INH (n = 8) in an ongoing trial of IPT in patients on ART. INH was associated with a 24% increase in median NVP area under the plasma concentration-time curve for the 12 h dosing interval, which was not statistically significant (P = 0.66).

PMID:
23407222
PMCID:
PMC4176729
DOI:
10.5588/ijtld.12.0427
[Indexed for MEDLINE]
Free PMC Article

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