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Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2013 Jan;38(1):43-7. doi: 10.3969/j.issn.1672-7347.2013.01.008.

[Effect of stellate ganglion block on reconstruction of the left ventricle in spontaneously hypertensive rats].

[Article in Chinese]

Author information

1
Department of Anesthesiology, Affiliated Hospital, Wannan Medical College, Wuhu Anhui 241001, China. chenyq263@163.com

Abstract

OBJECTIVE:

To determine the effect of stellate ganglion block on reconstruction of the left ventricle in spontaneously hypertensive rats (SHRs).

METHODS:

Thirty-two 10-week-old male SHRs were randomly assigned into 4 groups: a left stellate ganglion block group (group LS), a right stellate ganglion block group (group RS), a captopril group (group D) and a control group (group C). The arterial systolic blood pressure (SBP) was measured by ALC-NIBP measuring system. After 10 weeks, we observed the left ventricular mass index (LVMI), myocardial pathologic changes, and detected the endothelin (ET-1) and endothelial nitric oxide synthase (eNOS) level in the left ventricle by radioimmunoassay and the collagen protein level in the left ventricle by immunohistochemical method.

RESULTS:

Compared with group LS and group C, the LVMI in group RS was lowered most notably (P<0.05) and pathological changes were improved obviously. The expression of eNOS in group RS was significantly increased and ET-1 significantly decreased (P<0.05) compared with that in group C and group LS. The expression of type I collagen fibers in group RS was significantly lower and type III collagen fibers significantly higher (P<0.05) when compared with that in group C and LS.

CONCLUSION:

Right stellate ganglion block can not only decrease the arterial pressure but also reverse the reconstruction of the left ventricle.

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