Abstract
Innate lymphoid cells (ILCs) constitute a family of effectors in innate immunity and regulators of tissue remodeling that have a cytokine and transcription factor expression pattern that parallels that of the T-helper (Th) cell family. Here, we discuss how ILCs can be categorized and summarize the current knowledge of Th1- and Th2-like ILCs with regard to the molecular mechanisms of development, effector functions, and their interplay with other cell types.
© 2013 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd.
MeSH terms
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Animals
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Cell Differentiation
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Cell Lineage / immunology*
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Cytokines / genetics
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Cytokines / immunology
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Gene Expression Regulation
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Humans
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Immunity, Innate*
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Interleukin-7 Receptor alpha Subunit / genetics
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Interleukin-7 Receptor alpha Subunit / immunology
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Killer Cells, Natural / cytology
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Killer Cells, Natural / immunology
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Lymphocytes / classification
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Lymphocytes / cytology
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Lymphocytes / immunology*
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Mice
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Signal Transduction
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T-Lymphocyte Subsets / cytology
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T-Lymphocyte Subsets / immunology*
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Transcription Factors / genetics
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Transcription Factors / immunology
Substances
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Cytokines
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Interleukin-7 Receptor alpha Subunit
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Transcription Factors