Th1- and Th2-like subsets of innate lymphoid cells

Immunol Rev. 2013 Mar;252(1):133-8. doi: 10.1111/imr.12034.

Abstract

Innate lymphoid cells (ILCs) constitute a family of effectors in innate immunity and regulators of tissue remodeling that have a cytokine and transcription factor expression pattern that parallels that of the T-helper (Th) cell family. Here, we discuss how ILCs can be categorized and summarize the current knowledge of Th1- and Th2-like ILCs with regard to the molecular mechanisms of development, effector functions, and their interplay with other cell types.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Cell Lineage / immunology*
  • Cytokines / genetics
  • Cytokines / immunology
  • Gene Expression Regulation
  • Humans
  • Immunity, Innate*
  • Interleukin-7 Receptor alpha Subunit / genetics
  • Interleukin-7 Receptor alpha Subunit / immunology
  • Killer Cells, Natural / cytology
  • Killer Cells, Natural / immunology
  • Lymphocytes / classification
  • Lymphocytes / cytology
  • Lymphocytes / immunology*
  • Mice
  • Signal Transduction
  • T-Lymphocyte Subsets / cytology
  • T-Lymphocyte Subsets / immunology*
  • Transcription Factors / genetics
  • Transcription Factors / immunology

Substances

  • Cytokines
  • Interleukin-7 Receptor alpha Subunit
  • Transcription Factors