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Immunol Rev. 2013 Mar;252(1):104-15. doi: 10.1111/imr.12028.

Th9 cells: differentiation and disease.

Author information

1
Department of Pediatrics, Indiana University School of Medicine, HB Wells Center for Pediatric Research, Indianapolis, IN 46202, USA. mkaplan2@iupui.edu

Abstract

CD4(+) T-helper cells regulate immunity and inflammation through the acquisition of potential to secrete specific cytokines. The acquisition of cytokine-secreting potential, in a process termed T-helper cell differentiation, is a response to multiple environmental signals including the cytokine milieu. The most recently defined subset of T-helper cells are termed Th9 and are identified by the potent production of interleukin-9 (IL-9). Given the pleiotropic functions of IL-9, Th9 cells might be involved in pathogen immunity and immune-mediated disease. In this review, I focus on recent developments in understanding the signals that promote Th9 differentiation, the transcription factors that regulate IL-9 expression, and finally the potential roles for Th9 cells in immunity in vivo.

PMID:
23405898
PMCID:
PMC3982928
DOI:
10.1111/imr.12028
[Indexed for MEDLINE]
Free PMC Article

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