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Obesity (Silver Spring). 2013 Feb;21(2):251-3. doi: 10.1002/oby.20057.

How best to use partial meal replacement in managing overweight or obese patients with poorly controlled type 2 diabetes.

Author information

1
Diabetes Centre, Royal Prince Alfred Hospital, Sydney, Australia. natashajoleader@gmail.com

Abstract

OBJECTIVE:

To compare patient compliance and benefits, over 12 months, of 1 versus 2 partial meal replacement (PMR) for the management of overweight/obese subjects with inadequately controlled type 2 diabetes.

DESIGN AND METHODS:

Thirty-six overweight patients with inadequately controlled type 2 diabetes (BMI > 27 kg/m(2) and HbA1c > 7.5% [58 mmol/mol]) were randomized to receive 1 or 2 PMR/day, while maintaining usual lifestyle. Subjects were seen monthly and adjustment of medications was made to prevent hypoglycemia. Compliance was assessed by counting unused sachets.

RESULTS:

Patients on 2 PMR/day lost almost 4 kg compared with only 0.5 kg in the 1 PMR/day group. This difference was statistically significant (P < 0.05). Overall PMR was about 30% as effective as in our previous study on total meal replacement. Reductions in weight, waist, and HbA1c were better in the 2 PMR/day group while patient dropout and compliance were not worse over a 12-month period.

CONCLUSION:

PMR provides a further management option for overweight/obese individuals with type 2 diabetes. The initial recommendation should be 2 PMR/day.

PMID:
23404963
DOI:
10.1002/oby.20057
[Indexed for MEDLINE]
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