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Curr Psychiatry Rep. 2013 Mar;15(3):347. doi: 10.1007/s11920-012-0347-y.

Behavioral interventions for antipsychotic induced appetite changes.

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1
Department of Clinical Sciences, Division of Psychiatry, Umeå University, 90185 Umeå, Sweden. uwerneke@gmail.com

Abstract

Weight gain remains a well recognized yet difficult to treat adverse effect of many anti-psychotic drugs including agents of the first and second generation. The weight gain liabilities of antipsychotic drugs are partly associated with their ability to increase appetite. Most behavioral interventions for weight control remain of limited efficacy, possibly because they do not specifically target the neuroendocrine factors regulating appetite. Identifying new weight management interventions directly acting on the biochemical and neuroendocrine mechanisms of anti-psychotic induced weight gain may help to improve the efficacy of behavioral weight management programs. Such potentially specific strategies include (1) using diets which do not increase appetite despite calorie restriction; (2) countering thirst as an anticholinergic side-effect; (3) discouraging cannabis use and (4) adding metformin to a behavioral intervention. In view of our currently rather limited treatment repertoire it seems timely systematically to explore such novel options.

PMID:
23404388
PMCID:
PMC3586399
DOI:
10.1007/s11920-012-0347-y
[Indexed for MEDLINE]
Free PMC Article
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