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J Acquir Immune Defic Syndr. 2013 Jun 1;63(2):249-53. doi: 10.1097/QAI.0b013e31828a77f0.

Characteristics of B-cell lymphomas in HIV/HCV-coinfected patients during the combined antiretroviral therapy era: an ANRS CO16 LYMPHOVIR cohort study.

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  • 1Department of Internal Medicine II, Universit√© Paris 6 Pierre et Marie Curie UMR S 943, Paris, France.

Abstract

Hepatitis C virus (HCV) infection is frequent among HIV-infected patients. We describe, the characteristics of 6 HIV/HCV-coinfected patients with B-cell non-Hodgkin lymphoma (NHL) included in a prospective cohort study of HIV-related lymphomas. Five of the 6 cases had features of marginal zone/lymphoplasmacytic NHL versus 1 of 33 HIV only-infected patients. Remarkably, anti-HCV treatment led to a hematological response in a patient with splenic marginal zone lymphoma. This supports the role of chronic antigenic stimulation by HCV on lymphomagenesis and further evaluation of HCV antiviral therapy in coinfected patients with NHL.

PMID:
23403861
DOI:
10.1097/QAI.0b013e31828a77f0
[PubMed - indexed for MEDLINE]
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