Format

Send to

Choose Destination
Nat Rev Mol Cell Biol. 2013 Mar;14(3):166-80. doi: 10.1038/nrm3528. Epub 2013 Feb 13.

Exploring mechanisms of FGF signalling through the lens of structural biology.

Author information

1
Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, New York 10016, USA. Regina.Goetz@nyumc.org

Abstract

Fibroblast growth factors (FGFs) mediate a broad range of functions in both the developing and adult organism. The accumulated wealth of structural information on the FGF signalling pathway has begun to unveil the underlying molecular mechanisms that modulate this system to generate a myriad of distinct biological outputs in development, tissue homeostasis and metabolism. At the ligand and receptor level, these mechanisms include alternative splicing of the ligand (FGF8 subfamily) and the receptor (FGFR1-FGFR3), ligand homodimerization (FGF9 subfamily), site-specific proteolytic cleavage of the ligand (FGF23), and interaction of the ligand and the receptor with heparan sulphate cofactor and Klotho co-receptor.

PMID:
23403721
PMCID:
PMC3695728
DOI:
10.1038/nrm3528
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center