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Nat Commun. 2013;4:1479. doi: 10.1038/ncomms2484.

IGF-1 promotes the development and cytotoxic activity of human NK cells.

Author information

1
Institute of Immunology, School of Life Sciences, University of Science and Technology of China, 443 Huang-Shan Road, Hefei, Anhui Province 230027, China.

Abstract

Insulin-like growth factor 1 (IGF-1) is a critical regulator of many physiological functions, ranging from longevity to immunity. However, little is known about the role of IGF-1 in natural killer cell development and function. Here, we identify an essential role for IGF-1 in the positive regulation of human natural killer cell development and cytotoxicity. Specifically, we show that human natural killer cells have the ability to produce IGF-1 and that differential endogenous IGF-1 expression leads to disparate cytotoxicity in human primary natural killer cells. Moreover, miR-483-3p is identified as a critical regulator of IGF-1 expression in natural killer cells. Overexpression of miR-483-3p has an effect similar to IGF-1 blockade and decreased natural killer cell cytotoxicity, whereas inhibition of miR-483-3p has the opposite effect, which is reversible with IGF-1 neutralizing antibody. These findings indicate that IGF-1 and miR-483-3p belong to a new class of natural killer cell functional modulators and strengthen the prominent role of IGF-1 in innate immunity.

PMID:
23403580
PMCID:
PMC3586714
DOI:
10.1038/ncomms2484
[Indexed for MEDLINE]
Free PMC Article

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