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Antimicrob Agents Chemother. 2013 May;57(5):2365-8. doi: 10.1128/AAC.02288-12. Epub 2013 Feb 12.

Activities of systemically administered echinocandins against in vivo mature Candida albicans biofilms developed in a rat subcutaneous model.

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  • 1Department of Molecular Microbiology, VIB, KU Leuven, Leuven, Belgium.

Abstract

This study addresses the effects of micafungin, caspofungin, and anidulafungin against Candida albicans biofilms developed in a subcutaneous catheter rat model system. Doses of 5, 10, and 30 mg/kg (of body weight)/day (the last only for micafungin) were given intravenously for 5, 7, and 10 days. All three echinocandins caused a significant reduction of the Candida cell numbers on the implanted catheters and are thus promising for the treatment of biofilm-related infections.

PMID:
23403433
PMCID:
PMC3632894
DOI:
10.1128/AAC.02288-12
[PubMed - indexed for MEDLINE]
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