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Bioorg Med Chem Lett. 2013 Mar 15;23(6):1760-2. doi: 10.1016/j.bmcl.2013.01.045. Epub 2013 Jan 26.

Design, synthesis and aromatase inhibitory activities of novel indole-imidazole derivatives.

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1
Key Laboratory of Medicinal Chemistry for Natural Resource (Yunnan University), Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China.

Abstract

A series of novel indole-imidazole derivatives have been prepared and evaluated in vitro on the aromatase inhibitory activities. The results suggested that proton or a small electron-withdrawing group at para-position of the phenyl ring would enhance the inhibitory activities and any bulky group should be avoided in order to keep a relative small volume for this kind of molecules.

PMID:
23403081
DOI:
10.1016/j.bmcl.2013.01.045
[Indexed for MEDLINE]
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