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Bioorg Med Chem Lett. 2013 Mar 15;23(6):1803-7. doi: 10.1016/j.bmcl.2013.01.039. Epub 2013 Jan 23.

Synthesis and anti-Candida activity of novel 2-hydrazino-1,3-thiazole derivatives.

Author information

1
Institut des Biomole´cules Max Mousseron, UMR 5247, CNRS, Universite´s Montpellier I et II, UFR des Sciences Pharmaceutiques et Biologiques, 15 Avenue Charles Flahault, 34093 Montpellier Cedex 5, France. ludovic.maillard@univ-montp1.fr

Abstract

Eighteen new hydrazino-1,3-thiazole derivatives were evaluated against 8 strains of multi-resistant Candida spp. Introduction of an indolyl moiety linked to the hydrazone function enhanced the in vitro anti-Candida activity, with an activity spectrum towards Candida albicans strains. Introduction of a (S)-2-aminoethyl chain on the thiazole nucleus largely enhanced the in vitro antifungal activity, with a selectivity oriented towards non-C. albicans species.

PMID:
23403080
DOI:
10.1016/j.bmcl.2013.01.039
[Indexed for MEDLINE]

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