Send to

Choose Destination
Exp Gerontol. 2013 Oct;48(10):1129-35. doi: 10.1016/j.exger.2013.02.003. Epub 2013 Feb 10.

High carbohydrate-low protein consumption maximizes Drosophila lifespan.

Author information

Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, FL 33458, USA.


Dietary restriction extends lifespan in a variety of organisms, but the key nutritional components driving this process and how they interact remain uncertain. In Drosophila, while a substantial body of research suggests that protein is the major dietary component affecting longevity, recent studies claim that carbohydrates also play a central role. To clarify how nutritional factors influence longevity, nutrient consumption and lifespan were measured on a series of diets with varying yeast and sugar content. We show that optimal lifespan requires both high carbohydrate and low protein consumption, but neither nutrient by itself entirely predicts lifespan. Increased dietary carbohydrate or protein concentration does not always result in reduced feeding-the regulation of food consumption is best described by a constant daily caloric intake target. Moreover, due to differences in food intake, increased concentration of a nutrient within the diet does not necessarily result in increased consumption of that particular nutrient. Our results shed light on the issue of dietary effects on lifespan and highlight the need for accurate measures of nutrient intake in dietary manipulation studies.


Aging; C:P; Dietary restriction; Drosophila; Feeding; Longevity; Nutrition; carbohydrate protein ratio

[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center