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Cancer Lett. 2013 Jul 1;334(2):328-37. doi: 10.1016/j.canlet.2013.02.007. Epub 2013 Feb 10.

Enhanced drug delivery to melanoma cells using PMPC-PDPA polymersomes.

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1
The Krebs Institute, University of Sheffield, Sheffield, UK.

Abstract

We present the efficient and stable encapsulation of doxorubicin within pH sensitive polymeric vesicles (polymersomes) for intracellular and nuclear delivery to melanoma cells. We demonstrate that PMPC25-PDPA70 polymersomes can encapsulate doxorubicin for long periods of time without significant drug release. We demonstrate that empty polymersomes are non-toxic and that they are quickly and more efficiently internalised by melanoma cells compared to healthy cells. Encapsulated doxorubicin has a strong cytotoxic effect on both healthy and cancerous cells, but when encapsulated it had a preferential effect on melanoma cells indicating that this formulation can be used to achieve an enhanced drug delivery to cancerous cells rather than to the healthy surrounding cells.

PMID:
23402813
DOI:
10.1016/j.canlet.2013.02.007
[Indexed for MEDLINE]

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