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Trends Endocrinol Metab. 2013 Apr;24(4):200-8. doi: 10.1016/j.tem.2013.01.002. Epub 2013 Feb 8.

Nutrient transporters: the Achilles' heel of anabolism.

Author information

1
Department of Developmental and Cell Biology, University of California, Irvine, CA 92697, USA.

Abstract

Highly proliferative cells, including cancer cells, require a constant supply of molecular building blocks to support their growth. To acquire substrates such as glucose and amino acids from the extracellular space, dividing cells rely on transporter proteins in the plasma membrane. Numerous studies link transcriptional and post-translational control of nutrient transporter expression with proliferation, highlighting the importance of nutrient transporters in both physiologic and pathologic growth. Here we review recent work that spotlights the crucial role of nutrient transporters in cell growth and proliferation, discuss post-translational mechanisms for coordinating expression of different transporters, and consider the therapeutic potential of targeting these proteins in cancer and other diseases characterized by inappropriate cell division.

PMID:
23402769
PMCID:
PMC3617053
DOI:
10.1016/j.tem.2013.01.002
[Indexed for MEDLINE]
Free PMC Article

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