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Comput Math Methods Med. 2013;2013:141087. doi: 10.1155/2013/141087. Epub 2013 Jan 14.

Modelling tumour oxygenation, reoxygenation and implications on treatment outcome.

Author information

1
Medical Radiation Physics, Stockholm University and Karolinska Institutet, 171 76 Stockholm, Sweden. iuliana.livia.dasu@ki.se

Abstract

Oxygenation is an important component of the tumour microenvironment, having a significant impact on the progression and management of cancer. Theoretical determination of tissue oxygenation through simulations of the oxygen transport process is a powerful tool to characterise the spatial distribution of oxygen on the microscopic scale and its dynamics and to study its impact on the response to radiation. Accurate modelling of tumour oxygenation must take into account important aspects that are specific to tumours, making the quantitative characterisation of oxygenation rather difficult. This paper aims to discuss the important aspects of modelling tumour oxygenation, reoxygenation, and implications for treatment.

PMID:
23401721
PMCID:
PMC3557613
DOI:
10.1155/2013/141087
[Indexed for MEDLINE]
Free PMC Article
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