Format

Send to

Choose Destination
See comment in PubMed Commons below
Int J Cell Biol. 2013;2013:463637. doi: 10.1155/2013/463637. Epub 2013 Jan 21.

Alternative cell death pathways and cell metabolism.

Author information

1
Institute for Experimental Cancer Research in Pediatrics, Goethe-University Frankfurt, Komturstra├če 3a, 60528 Frankfurt, Germany.

Abstract

While necroptosis has for long been viewed as an accidental mode of cell death triggered by physical or chemical damage, it has become clear over the last years that necroptosis can also represent a programmed form of cell death in mammalian cells. Key discoveries in the field of cell death research, including the identification of critical components of the necroptotic machinery, led to a revised concept of cell death signaling programs. Several regulatory check and balances are in place in order to ensure that necroptosis is tightly controlled according to environmental cues and cellular needs. This network of regulatory mechanisms includes metabolic pathways, especially those linked to mitochondrial signaling events. A better understanding of these signal transduction mechanisms will likely contribute to open new avenues to exploit our knowledge on the regulation of necroptosis signaling for therapeutic application in the treatment of human diseases.

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Hindawi Publishing Corporation Icon for PubMed Central
    Loading ...
    Support Center