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Mov Disord. 2013 Apr;28(4):543-7. doi: 10.1002/mds.25354. Epub 2013 Feb 11.

The spectrum of movement disorders in children with anti-NMDA receptor encephalitis.

Author information

1
Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA.

Abstract

BACKGROUND:

Movement disorders are frequent but difficult to characterize in patients with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis.

METHODS:

The phenomenology of movement disorders was characterized after a detailed examination of children with anti-NMDAR-encephalitis.

RESULTS:

We studied 9 children (5 females), ages 3-14 years, with confirmed anti-NMDAR-encephalitis. All patients presented with at least 1 movement disorder, including chorea (n=4), stereotypic movements (n=4), ataxia (n=3), limb dystonia (n=2), limb myorhythmia (n=2), oromandibular dystonia (n=2), facial myorhythmia, blepharospasm, opisthotonus, athetosis, and tremor (n=1, each). More than a single movement disorder was observed in 6 of these patients. Resolution of the abnormal movements was observed in all patients with immunotherapy; 1 patient improved with tetrabenazine.

CONCLUSIONS:

A wide variety of movement disorders, often in combination, can be observed in children with anti-NMDAR encephalitis. Patients commonly present with more than a single movement disorder.

PMID:
23400857
DOI:
10.1002/mds.25354
[Indexed for MEDLINE]

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