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JAMA Neurol. 2013 Feb;70(2):254-7. doi: 10.1001/2013.jamaneurol.139.

Sporadic Jakob-Creutzfeldt disease presenting as primary progressive aphasia.

Author information

1
Department of Neurology, Memory and Aging Center, University of California, San Francisco, CA 94143-1207, USA.

Abstract

OBJECTIVE:

To report the clinical, neuropsychological, linguistic, imaging, and neuropathological features of a unique case of sporadic Jakob-Creutzfeldt disease in which the patient presented with a logopenic variant of primary progressive aphasia.

DESIGN:

Case report.

SETTING:

Large referral center for atypical memory and aging disorders, particularly Jakob-Creutzfeldt disease.

PATIENT:

Patient presenting with logopenic variant primary progressive aphasia initially thought to be due to Alzheimer disease.

RESULTS:

Despite the long, slow 3.5-year course, the patient was shown to have pathology-proven sporadic Jakob-Creutzfeldt disease.

CONCLUSIONS:

These findings expand the differential of primary progressive aphasia to include prion disease.

PMID:
23400721
PMCID:
PMC4365870
DOI:
10.1001/2013.jamaneurol.139
[Indexed for MEDLINE]
Free PMC Article
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