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Cancer Discov. 2013 Feb;3(2):141-4. doi: 10.1158/2159-8290.CD-12-0588.

Mitotic control of cancer stem cells.

Author information

1
Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.

Abstract

Cancer stem cells are self-renewing, tumorigenic cells at the apex of tumor hierarchies, and postulated to be quiescent in many tumor types. This issue of Cancer Discovery highlights a study that links the presentation of kinetochores within mitosis to an essential requirement for BUB1B/BubR1, broadening our understanding of the cell-cycle machinery in cancer stem cells.

PMID:
23400473
PMCID:
PMC3616319
DOI:
10.1158/2159-8290.CD-12-0588
[Indexed for MEDLINE]
Free PMC Article
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