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J Biomed Opt. 2013 Feb;18(2):26018. doi: 10.1117/1.JBO.18.2.026018.

Photoacoustic contrast imaging of biological tissues with nanodiamonds fabricated for high near-infrared absorbance.

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1
University of Kansas, Department of Pharmaceutical Chemistry, 2095 Constant Avenue, Lawrence, KS 66047, USA.

Abstract

Radiation-damaged nanodiamonds (DNDs) are potentially ideal optical contrast agents for photoacoustic (PA) imaging in biological tissues due to their low toxicity and high optical absorbance. PA imaging contrast agents have been limited to quantum dots and gold particles, since most existing carbon-based nanoparticles, including fluorescent nanodiamonds, do not have sufficient optical absorption in the near-infrared (NIR) range. A new DND by He+ ion beam irradiation with very high NIR absorption was synthesized. These DNDs produced a 71-fold higher PA signal on a molar basis than similarly dimensioned gold nanorods, and 7.1 fmol of DNDs injected into rodents could be clearly imaged 3 mm below the skin surface with PA signal enhancement of 567% using an 820-nm laser wavelength.

PMID:
23400417
PMCID:
PMC3569583
DOI:
10.1117/1.JBO.18.2.026018
[Indexed for MEDLINE]
Free PMC Article
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