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Nat Rev Genet. 2013 Mar;14(3):221-7. doi: 10.1038/nrg3415. Epub 2013 Feb 12.

Evaluating evolutionary models of stress-induced mutagenesis in bacteria.

Author information

1
Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK. craig.maclean@zoo.ox.ac.uk

Abstract

Increased mutation rates under stress allow bacterial populations to adapt rapidly to stressors, including antibiotics. Here we evaluate existing models for the evolution of stress-induced mutagenesis and present a new model arguing that it evolves as a result of a complex interplay between direct selection for increased stress tolerance, second-order selection for increased evolvability and genetic drift. Further progress in our understanding of the evolutionary biology of stress and mutagenesis will require a more detailed understanding both of the patterns of stress encountered by bacteria in nature and of the mutations that are produced under stress.

PMID:
23400102
DOI:
10.1038/nrg3415
[Indexed for MEDLINE]

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