Format

Send to

Choose Destination
Nat Rev Genet. 2013 Mar;14(3):191-203. doi: 10.1038/nrg3375. Epub 2013 Feb 12.

Organization and segregation of bacterial chromosomes.

Author information

1
Harvard Medical School, Department of Microbiology and Immunobiology, HIM 1025, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.

Abstract

The bacterial chromosome must be compacted more than 1,000-fold to fit into the compartment in which it resides. How it is condensed, organized and ultimately segregated has been a puzzle for over half a century. Recent advances in live-cell imaging and genome-scale analyses have led to new insights into these problems. We argue that the key feature of compaction is the orderly folding of DNA along adjacent segments and that this organization provides easy and efficient access for protein-DNA transactions and has a central role in driving segregation. Similar principles and common proteins are used in eukaryotes to condense and to resolve sister chromatids at metaphase.

PMID:
23400100
PMCID:
PMC3869393
DOI:
10.1038/nrg3375
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center