Format

Send to

Choose Destination
Med Chem. 2014;10(1):59-65.

Effect of stilbene and chalcone scaffolds incorporation in clofibric acid on PPARα agonistic activity.

Author information

1
Dipartimento di Farmacia, Università di Chieti, via dei Vestini, 66100 Chieti, Italy. ramoroso@unich.it.

Abstract

In an effort to develop safe and efficacious compounds for the treatment of metabolic disorders, new compounds based on a combination of clofibric acid, the active metabolite of clofibrate, and trans-stilbene, chalcone, and other lipophilic groups were synthesized. They were evaluated for PPARα transactivation activity; all branched derivatives showed an increase of the transcriptional activity of receptor compared to the linear ones. Noteworthy, stilbene and benzophenone branched derivatives activated the PPARα better than clofibric acid.

PMID:
23432317
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Bentham Science Publishers Ltd.
Loading ...
Support Center