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Clin Chem Lab Med. 2013 Jul;51(7):1363-8. doi: 10.1515/cclm-2012-0653.

Psoriasis, a new challenge for laboratory medicine.

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1
Clinical Pathology Unit, Department of Health Sciences, University Magna Graecia, Catanzaro, Italy. gulletta@unicz.it

Abstract

Psoriasis is an immune-mediated, chronic, inflammatory disease that affects the skin and joints. Because of its high incidence and of its clinical symptoms it has a very strong social impact. In a genetically predisposed individual, the maintenance of the skin barrier integrity is strongly compromised in response to either environmental or self-antigenic insults. A persistent dysregulation of the skin immune system causes the typical evolutive skin lesions of psoriasis and recurrence of the disease. The most efficient laboratory approach consists of a well-defined evaluation of immune response in order to help diagnosis, to monitor evolution, and to evaluate the effects of individualized therapeutic treatments.

PMID:
23399587
DOI:
10.1515/cclm-2012-0653
[Indexed for MEDLINE]
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