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Carbohydr Polym. 2013 Feb 15;92(2):2321-6. doi: 10.1016/j.carbpol.2012.11.062. Epub 2012 Dec 10.

Kinetics and mechanism of oxidation of chondroitin-4-sulfate polysaccharide by chromic acid in aqueous perchlorate solutions.

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Chemistry Department, Faculty of Science, Assiut University, Assiut 71516, Egypt.


The kinetics of chromic acid oxidation of chondroitin-4-sulfate polysaccharide as sulfated carbohydrates at a constant ionic strength of 4.0 mol dm(-3) has been investigated, spectrophotometrically. The reaction kinetics showed a first-order dependence in chromic acid and fractional-first-order kinetics with respect to the chondroitin-4-sulfate concentration. The influence of [H(+)] on the reaction rates showed that the oxidation process is acid-catalyzed. Added Mn(2+) ions indicated the formation of Cr(IV) as intermediate species. A kinetic evidence for formation of 1:1 intermediate complex was revealed. The kinetic parameters have been evaluated and a tentative reaction mechanism in good consistent with the kinetic results obtained is discussed.

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