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Carbohydr Polym. 2013 Feb 15;92(2):2111-7. doi: 10.1016/j.carbpol.2012.11.074. Epub 2012 Dec 3.

Characterization of a heteropolysaccharide isolated from diploid Gynostemma pentaphyllum Makino.

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State Key Lab of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, Jiangsu, China.


A novel water-soluble polysaccharide (GPP), with a molecular mass of 7.1×10(3) Da, was isolated from the defatted whole-plant of diploid Gynostemma pentaphyllum Makino. Monosaccharide composition analysis indicated that GPP was a heteropolysaccharide mainly containing mannose, glucose, galactose and arabinose, at a molar ratio of 1.00:77.33:4.81:1.83. The detailed structure analysis revealed that GPP consisted of a (1→4)-α-D-glucoside backbone with a 1→)-α-D-glucopyranosyl branch at the C-6 position of (1→4,6)-linked-α-D-glucopyranosyl on every 5 monosaccharide residues, with a few mannose, galactose and arabinose terminal residues. GPP exhibited scavenging capacities against hydroxyl, peroxyl and DPPH radicals in vitro, and had a greater bile acid-binding ability than psyllium on a per weight basis. These results suggested a potential application of GPP in functional foods and dietary supplements.

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