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Carbohydr Polym. 2013 Feb 15;92(2):1835-43. doi: 10.1016/j.carbpol.2012.11.082. Epub 2012 Dec 3.

Spectroscopic investigation on the inclusion complex formation between amisulpride and γ-cyclodextrin.

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1
Department of Pharmaceutical Sciences, S Bhagwan Singh PG Institute of Bio-medical Sciences and Research, Balawala, Dehradun 248161, Uttarakhand, India. rx.jnegi@gmail.com

Abstract

The purpose of this research was to investigate inclusion complex formation between poorly soluble drug amisulpride (AMI) and γ-cyclodextrin (γ-CD). The solubility of AMI was enhanced by formation of inclusion complex of AMI with nano-hydrophobic cavity of γ-CD. The stoichiometry of inclusion complex was studied by continuous variation Job's plot method and found 1:1. The binding constant was found 1166.65 M(-1) by Benesi-Hildebrand plot. The molecular docking of AMI and γ-CD was done to investigate complexation. The inclusion complex formation was further confirmed by (1)H NMR and FT-IR, DSC and XRD analysis. The solubility of AMI was increased 3.74 times after inclusion complex formation with γ-CD.

PMID:
23399226
DOI:
10.1016/j.carbpol.2012.11.082
[Indexed for MEDLINE]
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