Format

Send to

Choose Destination
See comment in PubMed Commons below
Clin Implant Dent Relat Res. 2014 Oct;16(5):675-83. doi: 10.1111/cid.12045. Epub 2013 Feb 7.

Accelerated and enhanced bone formation on novel simvastatin-loaded porous titanium oxide surfaces.

Author information

1
Department of Prosthodontics, University of Dental Medicine, Yangon, Myanmar; Department of Oral Implantology and Regenerative Dental Medicine, Tokyo Medical and Dental University, Tokyo, Japan; Global Center of Excellence Program, International Research Center for Molecular Science in Tooth and Bone Diseases, Tokyo Medical and Dental University, Tokyo, Japan.

Abstract

BACKGROUND:

With increasing application of dental implants in poor-quality bones, the need for implant surfaces ensuring accelerated osseointegration and enhanced peri-implant bone regeneration is increased.

PURPOSE:

A study was performed to evaluate the osseointegration and bone formation on novel simvastatin-loaded porous titanium oxide surface.

MATERIALS AND METHODS:

Titanium screws were treated by micro-arc oxidation to form porous oxide surface and 25 or 50 μg of simvastatin was loaded. The nontreated control, micro-arc oxidized, and simvastatin-loaded titanium screws were surgically implanted into the proximal tibia of 16-week-old male Wistar rats (n = 36). Peri-implant bone volume, bone-implant contact, and mineral apposition rates were measured at 2 and 4 weeks. Data were analyzed by one-way analysis of variance followed by Tukey's post hoc test.

RESULTS:

New bone was formed directly on the implant surface in the bone marrow cavity in simvastatin-loaded groups since 2 weeks. Bone-implant contact values were significantly higher in simvastatin-loaded groups than control and micro-arc oxidized groups at both time points (p < .05). Peri-implant bone volume and mineral apposition rate of simvastatin-loaded groups were significantly higher than control and micro-arc oxidized groups at 2 weeks (p < .05).

CONCLUSIONS:

These data suggested that simvastatin-loaded porous titanium oxide surface provides faster osseointegration and peri-implant bone formation and it would be potentially applicable in poor-quality bones.

KEYWORDS:

bone regeneration; micro-arc oxidation; osseointegration; simvastatin; titanium oxide

PMID:
23399109
DOI:
10.1111/cid.12045
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center