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J Appl Microbiol. 2013 May;114(5):1285-93. doi: 10.1111/jam.12162. Epub 2013 Mar 1.

The antibiofilm effects of Byotrol™ G32.

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1
School of Medicine, University of Manchester, Manchester, UK.

Abstract

AIM:

The purpose of this study was to evaluate a commercial antimicrobial formulation, Byotrol™ G32, as a potential coating for impeding biofilm formation on medical devices such as urinary catheters.

METHODS AND RESULTS:

The antimicrobial activity of Byotrol™ G32 and its individual constituents has been tested on planktonic and biofilm cultures of uropathogenic bacteria. The Byotrol™ G32 formulation was superior with MICs ranging from 3 μg ml(-1) to 15 μg ml(-1) for planktonic cultures and 3-20 μg ml(-1) for biofilms. Furthermore, Byotrol™ G32 was able to remove established biofilms and act as an antibiofilm surface coating.

CONCLUSIONS:

Byotrol™ G32 displays impressive antimicrobial activity both in suspension and as a coating. Pretreating medical devices with Byotrol™ G32 may significantly impede biofilm formation and prolong the lifetime of the device.

SIGNIFICANCE AND IMPACT OF THE STUDY:

Medical devices are indispensable in health care. They are, however, a predisposing factor in infection. This research has demonstrated that Byotrol™ G32 reduces bacterial growth and subsequent biofilm formation. Application of Byotrol™ G32 as a medical device coating could have a significant impact on the costs associated with device replacement and patient morbidity and mortality.

PMID:
23398275
DOI:
10.1111/jam.12162
[Indexed for MEDLINE]
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