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Zhongguo Zhong Yao Za Zhi. 2012 Nov;37(21):3182-4.

[Stable life predection of Hangbaiju and Gongju by classic constant temperature accelerated test method].

[Article in Chinese]

Author information

1
Institute of Chinese Materia Medica, Henan University, Kaifeng 475004, China.

Abstract

OBJECTIVE:

To study the stability of chlorogenic acid, cynaroside and 3,5-O-discaffeoylquinc acid in Hangbaiju and Gongju and to predict their term of validity.

METHOD:

Hangbaiju and Gongju were incubated in an environmental chamber at different temperatures and relative humidities. After the incubation, quantitative determination of chlorogenic acid, cynaroside, 3,5-O-discaffeoylquinc acid in Hangbaiju and Gongju were measured by HPLC. The effective period of the preparation was calculated according to Arrhinius index law. Quantitative determination of 3,5-O-discaffeoylquinc acid, cynaroside, chlorogenic acid in Hangju and Gongju were analyzed by HPLC.

RESULT:

The stable life of Hangbaiju has been determined as 2.25 years. The stable life of Gongju has been determined as 4.31 years.

CONCLUSION:

The high temperature is not conducive to the stability of Hangbaiju and Gongju, which needs to be placed in a dark and cool place.

PMID:
23397708
[Indexed for MEDLINE]
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