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Blood. 2013 Apr 11;121(15):2845-53. doi: 10.1182/blood-2012-11-292037. Epub 2013 Feb 8.

Role of LRF/Pokemon in lineage fate decisions.

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1
Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Boston, MA, USA.

Abstract

In the human genome, 43 different genes are found that encode proteins belonging to the family of the POK (poxvirus and zinc finger and Krüppel)/ZBTB (zinc finger and broad complex, tramtrack, and bric à brac) factors. Generally considered transcriptional repressors, several of these genes play fundamental roles in cell lineage fate decision in various tissues, programming specific tasks throughout the life of the organism. Here, we focus on functions of leukemia/lymphoma-related factor/POK erythroid myeloid ontogenic factor, which is probably one of the most exciting and yet enigmatic members of the POK/ZBTB family.

PMID:
23396304
PMCID:
PMC3624932
DOI:
10.1182/blood-2012-11-292037
[Indexed for MEDLINE]
Free PMC Article
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