Format

Send to

Choose Destination
Nat Immunol. 2013 Apr;14(4):404-12. doi: 10.1038/ni.2536. Epub 2013 Feb 10.

Transcriptional insights into the CD8(+) T cell response to infection and memory T cell formation.

Author information

1
Division of Biological Sciences, University of California San Diego, La Jolla, California, USA.

Abstract

After infection, many factors coordinate the population expansion and differentiation of CD8+ effector and memory T cells. Using data of unparalleled breadth from the Immunological Genome Project, we analyzed the CD8+ T cell transcriptome throughout infection to establish gene-expression signatures and identify putative transcriptional regulators. Notably, we found that the expression of key gene signatures can be used to predict the memory-precursor potential of CD8+ effector cells. Long-lived memory CD8+ cells ultimately expressed a small subset of genes shared by natural killer T and γδ T cells. Although distinct inflammatory milieu and T cell precursor frequencies influenced the differentiation of CD8+ effector and memory populations, core transcriptional signatures were regulated similarly, whether polyclonal or transgenic, and whether responding to bacterial or viral model pathogens. Our results provide insights into the transcriptional regulation that influence memory formation and CD8+ T cell immunity.

PMID:
23396170
PMCID:
PMC3689652
DOI:
10.1038/ni.2536
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center