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Nat Neurosci. 2013 Mar;16(3):264-6. doi: 10.1038/nn.3329. Epub 2013 Feb 10.

Long-term dynamics of CA1 hippocampal place codes.

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1
James H. Clark Center, Stanford University, Stanford, California, USA.

Abstract

Using Ca(2+) imaging in freely behaving mice that repeatedly explored a familiar environment, we tracked thousands of CA1 pyramidal cells' place fields over weeks. Place coding was dynamic, as each day the ensemble representation of this environment involved a unique subset of cells. However, cells in the ∼15-25% overlap between any two of these subsets retained the same place fields, which sufficed to preserve an accurate spatial representation across weeks.

PMID:
23396101
PMCID:
PMC3784308
DOI:
10.1038/nn.3329
[Indexed for MEDLINE]
Free PMC Article
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