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Pancreatology. 2013 Jan-Feb;13(1):29-32. doi: 10.1016/j.pan.2012.12.059. Epub 2012 Dec 20.

The number of tandem repeats in the carboxyl-ester lipase (CEL) gene as a risk factor in alcoholic and idiopathic chronic pancreatitis.

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1
KG Jebsen Center for Diabetes Research, Department of Clinical Medicine, University of Bergen, Bergen, Norway.

Abstract

BACKGROUND/AIMS:

The variable number of tandem repeats (VNTR) in the last exon of the carboxyl-ester lipase (CEL) gene has been reported to associate with alcohol-induced chronic pancreatitis (ACP) in a Japanese study. Here, we have investigated the association between the number of CEL VNTR repeats and ACP or idiopathic chronic pancreatitis (ICP) in a cohort of German patients.

METHODS:

Patients diagnosed with ACP (n = 203) or ICP (n = 64) were genotyped using a screening method consisting of PCR followed by DNA fragment analysis. The allele frequencies of different CEL VNTR lengths were compared to the frequencies in healthy controls (n = 390).

RESULTS:

We observed no statistical significant associations between CEL VNTR allele frequencies and ACP or ICP.

CONCLUSION:

This study did not find evidence that supported an association between the common length variations of the CEL VNTR and chronic pancreatitis.

PMID:
23395566
DOI:
10.1016/j.pan.2012.12.059
[Indexed for MEDLINE]
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