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Cell Stem Cell. 2013 Feb 7;12(2):152-65. doi: 10.1016/j.stem.2013.01.001.

Mechanisms that regulate stem cell aging and life span.

Author information

1
Children's Research Institute, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Abstract

Mammalian aging is associated with reduced tissue regeneration, increased degenerative disease, and cancer. Because stem cells regenerate many adult tissues and contribute to the development of cancer by accumulating mutations, age-related changes in stem cells likely contribute to age-related morbidity. Consistent with this, stem cell function declines with age in numerous tissues as a result of gate-keeping tumor suppressor expression, DNA damage, changes in cellular physiology, and environmental changes in tissues. It remains unknown whether declines in stem cell function during aging influence organismal longevity. However, mechanisms that influence longevity also modulate age-related morbidity, partly through effects on stem cells.

PMID:
23395443
PMCID:
PMC3641677
DOI:
10.1016/j.stem.2013.01.001
[Indexed for MEDLINE]
Free PMC Article
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