Format

Send to

Choose Destination
Mol Cell. 2013 Feb 7;49(3):379-87. doi: 10.1016/j.molcel.2013.01.019.

Nutrient sensing, metabolism, and cell growth control.

Author information

1
Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.

Abstract

Cell growth is regulated by coordination of both extracellular nutrients and intracellular metabolite concentrations. AMP-activated kinase and mammalian target of rapamycin complex 1 serve as key molecules that sense cellular energy and nutrients levels, respectively. In addition, the members of the dioxygenase family, including prolylhydroxylase, lysine demethylase, and DNA demethylase, have emerged as possible sensors of intracellular metabolic status. The interplay among nutrients, metabolites, gene expression, and protein modification are involved in the coordination of cell growth with extracellular and intracellular conditions.

PMID:
23395268
PMCID:
PMC3587157
DOI:
10.1016/j.molcel.2013.01.019
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center