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Curr Opin Pharmacol. 2013 Apr;13(2):180-5. doi: 10.1016/j.coph.2013.01.002. Epub 2013 Mar 12.

Conundrum of angiotensin II and TGF-β interactions in aortic aneurysms.

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1
Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY 40536, United States.

Abstract

Angiotensin II (AngII) has been invoked as a principal mediator for the development and progression of both thoracic and abdominal aortic aneurysms. While there is consistency in experimental and clinical studies that overactivation of the renin angiotensin system promotes aortic aneurysm development, there are many unknowns regarding the mechanistic basis underlying AngII-induced aneurysms. Interactions of AngII with TGF-β in both thoracic and abdominal aortic aneurysms have been the focus of recent studies. While these studies have demonstrated profound effects of manipulating TGF-β activity on AngII-induced aortic aneurysms, they have also led to more questions regarding the interactions between AngII and this multifunctional cytokine. This review compiled the recent literature to provide insights into understanding the potentially complex interactions between AngII and TGF-β in the development of aortic aneurysms.

PMID:
23395156
PMCID:
PMC3691307
DOI:
10.1016/j.coph.2013.01.002
[Indexed for MEDLINE]
Free PMC Article
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