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Fertil Steril. 2013 May;99(6):1654-62. doi: 10.1016/j.fertnstert.2013.01.092. Epub 2013 Feb 5.

The influence of female and male body mass index on live births after assisted reproductive technology treatment: a nationwide register-based cohort study.

Author information

1
Section of Social Medicine, Department of Public Health, University of Copenhagen, Copenhagen, Denmark. gilp@sund.ku.dk

Abstract

OBJECTIVE:

To investigate the independent and combined associations between female and male body mass index (BMI) on the probability of achieving a live birth after treatments with in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) under adjustment for relevant covariates.

DESIGN:

Population-based cohort study.

SETTING:

Danish national registers.

PATIENT(S):

Patients with permanent residence in Denmark receiving IVF or ICSI treatment with use of autologous oocytes from January 1, 2006, to September 30, 2010.

INTERVENTION(S):

None.

MAIN OUTCOME MEASURE(S):

Live birth. Analyses were adjusted for age and smoking at treatment initiation and results stratified by BMI groups and presented by IVF/ICSI treatment.

RESULT(S):

In total, 12,566 women and their partners went through 25,191 IVF/ICSI cycles with 23.7% ending in a live birth. Overweight and obese women with regular ovulation had reduced odds of live birth (adjusted OR 0.88, 95% CI 0.79-0.99 and adjusted OR 0.75, 95% CI 0.63-0.90, respectively) compared with normal-weight women. IVF-treated couples with both partners having BMI ≥25 kg/m(2) had the lowest odds of live birth (adjusted OR 0.73, 95% CI 0.48-1.11) compared with couples with BMI <25 kg/m(2). BMI showed no significant effect on chance of live birth after ICSI.

CONCLUSION(S):

Increased female and male BMI, both independently and combined, negatively influenced live birth after IVF treatments. With ICSI, the association with BMI was less clear.

[Indexed for MEDLINE]

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