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G Ital Med Lav Ergon. 2011 Jul-Sep;33(3 Suppl):108-11.

[Clinical and biological prognostic factors in 135 patients affected by sinonasal carcinoma treated in Piedmont].

[Article in Italian]

Author information

1
Clinica ORL, Dipartimento di Fisiopatologia Clinica, Università degli Studi di Torino, Via Genova 3, 10126 Torino, Italy.

Abstract

Clinical and biological prognostic factors in 135 patients affected by sinonasal carcinoma treated in Piedmont. Long-term survival of patients with sinonasal carcinoma remains disappointing in spite of aggressive treatment. The aim of the study is the assessment of overall survival in a group of patients treated with a fixed protocol and the positivity of proliferation and neoangiogenesis markers (Ki-67 and VEGF). From our data it comes out that staging, histological type and treatment are the most important clinical and pathological prognostic factors, moreover surgery +/- radiotherapy is the first line treatment for these tumors. Proliferation index and neoangiogenesis plays a pivotal role in the natural history of such neoplasms.

PMID:
23393815
[Indexed for MEDLINE]
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