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PLoS One. 2013;8(2):e55532. doi: 10.1371/journal.pone.0055532. Epub 2013 Feb 5.

The oncogenic role of microRNA-130a/301a/454 in human colorectal cancer via targeting Smad4 expression.

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1
Department of General Surgery, PLA General Hospital, Beijing, China.

Abstract

Transforming growth factor (TGF)-β/Smad signaling plays an important role in colon cancer development, progression and metastasis. In this study we demonstrated that the microRNA-130a/301a/454 family is up-regulated in colon cancer tissues compared to paired adjacent normal mucosa, which share the same 3'-untranslational region (3'-UTR) binding seed sequence and are predicated to target Smad4. In colorectal cancer HCT116 and SW480 cells, overexpression of miRNA-130a/301a/454 mimics enhances cell proliferation and migration, while inhibitors of these miRNAs affect cell survival. The biological function of miRNA-130a/301a/454 on colon cancer cells is likely mediated by suppression of Smad4, and the up-regulation of the miRNAs is correlated with Smad4 down-regulation in human colon cancers. Collectively, these results suggest that miRNA-130a/301a/454 are novel oncogenic miRNAs contributing to colon tumorigenesis by regulating TGF-β/Smad signaling, which may have potential application in cancer therapy.

PMID:
23393589
PMCID:
PMC3564758
DOI:
10.1371/journal.pone.0055532
[Indexed for MEDLINE]
Free PMC Article
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