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EMBO Rep. 2013 Mar 1;14(3):284-91. doi: 10.1038/embor.2013.6. Epub 2013 Feb 8.

FIP200 regulates targeting of Atg16L1 to the isolation membrane.

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1
Department of Physiology and Cell Biology, Tokyo Medical and Dental University, Tokyo 113-8519, Japan.

Abstract

Autophagosome formation is a dynamic process that is strictly controlled by autophagy-related (Atg) proteins. However, how these Atg proteins are recruited to the autophagosome formation site or autophagic membranes remains poorly understood. Here, we found that FIP200, which is involved in proximal events, directly interacts with Atg16L1, one of the downstream Atg factors, in an Atg14- and phosphatidylinositol 3-kinase-independent manner. Atg16L1 deletion mutants, which lack the FIP200-interacting domain, are defective in proper membrane targeting. Thus, FIP200 regulates not only early events but also late events of autophagosome formation through direct interaction with Atg16L1.

PMID:
23392225
PMCID:
PMC3589088
DOI:
10.1038/embor.2013.6
[Indexed for MEDLINE]
Free PMC Article
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