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Nat Rev Immunol. 2013 Mar;13(3):190-8. doi: 10.1038/nri3386. Epub 2013 Feb 8.

Circadian control of the immune system.

Author information

1
Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, New York 10461, USA. christoph.scheiermann@med.uni-muenchen.de

Abstract

Circadian rhythms, which have long been known to play crucial roles in physiology, are emerging as important regulators of specific immune functions. Circadian oscillations of immune mediators coincide with the activity of the immune system, possibly allowing the host to anticipate and handle microbial threats more efficiently. These oscillations may also help to promote tissue recovery and the clearance of potentially harmful cellular elements from the circulation. This Review summarizes the current knowledge of circadian rhythms in the immune system and provides an outlook on potential future implications.

PMID:
23391992
PMCID:
PMC4090048
DOI:
10.1038/nri3386
[Indexed for MEDLINE]
Free PMC Article

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