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J Cyst Fibros. 2013 Dec;12(6):754-60. doi: 10.1016/j.jcf.2013.01.005. Epub 2013 Feb 5.

Peripheral neuropathy in cystic fibrosis: a prevalence study.

Author information

1
Department of Pediatrics, All India Institute of Medical Sciences, New Delhi-110029, India.

Abstract

BACKGROUND:

Information on peripheral neuropathy in children with cystic fibrosis is scanty. The etiology can be multifactorial (micronutrient deficiency, chronic hypoxia, impaired glucose tolerance, immunological, vasculopathic, critical illness).

METHODS:

Forty five cystic fibrosis children aged 1-18 years on vitamin E supplementation for at least 6 months underwent detailed neurological examination, serum vitamin E, vitamin B12, folate, copper levels and detailed nerve conduction studies.

RESULTS:

The mean age of the study population was 8.35 years (±4.9 years) with 62.2% being males. Overall 22 out of 45 (48.88%,CI: 33.7-64.2) had electrophysiological evidence of peripheral neuropathy which was predominantly axonal (86.4%), sensory (50%), and polyneuropathy (95.45%). There was no significant association between status of serum micronutrients and electrophysiological evidence of peripheral neuropathy.

CONCLUSION:

Patients with cystic fibrosis have electrophysiological evidence of peripheral neuropathy (predominantly axonal, sensory and polyneuropathy). There is significant association of higher chronological age with occurrence of peripheral neuropathy.

KEYWORDS:

Axonal; Cystic fibrosis; Micronutrients; Polyneuropathy; Sensory

PMID:
23391476
DOI:
10.1016/j.jcf.2013.01.005
[Indexed for MEDLINE]
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