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Curr Biol. 2013 Feb 4;23(3):R110-2. doi: 10.1016/j.cub.2012.12.021.

Intestinal regeneration: YAP-tumor suppressor and oncoprotein?

Author information

1
Hubrecht Institute - KNAW and University Medical Centre Utrecht, Uppsalalaan 8, 3584CT Utrecht, The Netherlands. vli@nimr.mrc.ac.uk

Abstract

The Hippo signaling pathway exerts a growth-suppressive effect by inhibitory phosphorylation of the oncogenic transcription co-activator Yki/YAP. A recent study paradoxically reports that genetic removal of YAP enhances intestinal stem cell expansion and regeneration.

PMID:
23391384
DOI:
10.1016/j.cub.2012.12.021
[Indexed for MEDLINE]
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