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Curr Biol. 2013 Feb 4;23(3):R104-6. doi: 10.1016/j.cub.2012.12.008.

Allergy: airway epithelial Rac1 suppresses allergic inflammation.

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1
Program in Cell Biology, Department of Pediatrics, National Jewish Health, 1400 Jackson St, Denver, CO 80206, USA. Hensonp@njhealth.org

Abstract

Loss of Rac1 in airway epithelial cells has demonstrated its participation in the ingestion of apoptotic cells and, more importantly, has revealed an unexpected role for Rac1 in maintaining the anti-inflammatory and non-immunogenic environment of the lung and reducing the intensity of allergic sensitization.

PMID:
23391381
DOI:
10.1016/j.cub.2012.12.008
[Indexed for MEDLINE]
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