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Endocrinol Metab Clin North Am. 2013 Mar;42(1):15-38. doi: 10.1016/j.ecl.2012.11.005. Epub 2012 Dec 12.

Defective counterregulation and hypoglycemia unawareness in diabetes: mechanisms and emerging treatments.

Author information

1
Division of Endocrinology, Metabolism & Lipid Research, Department of Medicine, Washington University, St Louis, MO 63110, USA.

Abstract

For people with diabetes, hypoglycemia remains the limiting factor in achieving glycemic control. This article reviews recent advances in how the brain senses and responds to hypoglycemia. Novel mechanisms by which individuals with insulin-treated diabetes develop hypoglycemia unawareness and impaired counterregulatory responses are outlined. Prevention strategies for reducing the incidence of hypoglycemia are discussed.

PMID:
23391237
PMCID:
PMC3568263
DOI:
10.1016/j.ecl.2012.11.005
[Indexed for MEDLINE]
Free PMC Article

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