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Biol Direct. 2013 Feb 7;8:5. doi: 10.1186/1745-6150-8-5.

GABBR1 has a HERV-W LTR in its regulatory region--a possible implication for schizophrenia.

Author information

1
CEITEC-Central European Institute of Technology, Masaryk University, CZ-62500, Brno, Czech Republic. hegyihedi@gmail.com

Abstract

Schizophrenia is a complex disease with uncertain aetiology. We suggest GABBR1, GABA receptor B1 implicated in schizophrenia based on a HERV-W LTR in the regulatory region of GABBR1. Our hypothesis is supported by: (i) GABBR1 is in the 6p22 genomic region most often implicated in schizophrenia; (ii) microarray studies found that only presynaptic pathway-related genes, including GABA receptors, have altered expression in schizophrenic patients and (iii) it explains how HERV-W elements, expressed in schizophrenia, play a role in the disease: by altering the expression of GABBR1 via a long terminal repeat that is also a regulatory element to GABBR1.

PMID:
23391219
PMCID:
PMC3574838
DOI:
10.1186/1745-6150-8-5
[Indexed for MEDLINE]
Free PMC Article

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