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Hemoglobin. 2013;37(2):197-200. doi: 10.3109/03630269.2013.768532. Epub 2013 Feb 8.

Detection of Hb Constant Spring [α142, Term→Gln, TAA>CAA (α2)] in heterozygotes combined with β-thalassemia.

Author information

1
Clinical Laboratory, the People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, People's Republic of China.

Abstract

Hb Constant Spring [Hb CS, α142, Term→Gln, TAA>CAA (α2)] is a nondeletional form of α-thalassemia (α-thal) that is most prevalent in Southern Chinese and Southeast Asian populations. We previously found that Hb CS trait could efficiently be screened using Sebia Capillarys2. In this study, we report that Hb CS heterozygotes combined with β-thal could not be detected by the Sebia Capillarys2 method due to the very small amount of Hb CS.

PMID:
23390935
DOI:
10.3109/03630269.2013.768532
[Indexed for MEDLINE]

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